Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366838 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
4-Amino-5,6-biaryl-furo[2,3-d]pyrimidines were identified as potent non-selective inhibitors of Lck. A novel, divergent, and practical synthetic route was developed to access derivatives from bifunctional intermediates. Lead optimization was guided by X-ray crystallographic data, and preliminary SAR led to the identification of compounds with improved cellular potency and selectivity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Erin F. DiMauro, John Newcomb, Joseph J. Nunes, Jean E. Bemis, Christina Boucher, John L. Buchanan, William H. Buckner, Alan Cheng, Theodore Faust, Faye Hsieh, Xin Huang, Josie H. Lee, Teresa L. Marshall, Matthew W. Martin, David C. McGowan,