| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366840 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A novel series of potent dual agonists of PPARα and PPARγ, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure–activity relationships of this series of dual PPARα/γ agonists are described.
Graphical abstractA novel series of potent dual agonists of PPARα and PPARγ, the oxybenzylglycines, were identified and explored using a solution-phase library approach. The synthesis and structure–activity relationships of this series of dual PPARα/γ agonists are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pratik V. Devasthale, Sean Chen, Yoon Jeon, Fucheng Qu, Denis E. Ryono, Wei Wang, Hao Zhang, Lin Cheng, Dennis Farrelly, Rajasree Golla, Gary Grover, Zhengping Ma, Lisa Moore, Ramakrishna Seethala, Wei Sun, Arthur M. Doweyko, Gamini Chandrasena,