| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366841 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
The discovery and synthesis of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor 1-receptor (IGF-1R) are presented. Installing amine containing side chains at the 4-position of pyridone ring significantly improved the enzyme potency. SAR and biological activity of these compounds is presented.
Graphical abstractThe discovery and synthesis of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) are presented. Installing amine containing side chains at the 4-position of pyridone ring significantly improved the enzyme potency. SAR and biological activity of these compounds are presented.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)](/preview/png/1366841.png "First Page Preview: Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)")
Authors
Upender Velaparthi, Mark Wittman, Peiying Liu, Karen Stoffan, Kurt Zimmermann, Xiaopeng Sang, Joan Carboni, Aixin Li, Ricardo Attar, Marco Gottardis, Ann Greer, ChiehYing Y. Chang, Bruce L. Jacobsen, John S. Sack, Yax Sun, David R. Langley,