| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366843 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
In this paper, we describe the synthesis of a selected library of heterochiral d-Pro-containing RGD-peptidomimetics (RpD) and we investigate the biological activity as inhibitors of fibronectin adhesion to SK-MEL-24 tumor cells. In particular, peptides 4 and 8 showed an IC50 in the 10−8 M range. Despite the linear structure, the peptides tend to adopt a folded conformation in a polar environment.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Luca Gentilucci, Giuliana Cardillo, Federico Squassabia, Alessandra Tolomelli, Santi Spampinato, Antonino Sparta, Monica Baiula,