| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366850 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Antimicrobial peptides have been recognized as a novel class of antibiotics, and several candidates are currently in clinical trials. In this work, a tripeptide derivative containing 4-iodo phenylalanine has been derivatized through the Suzuki–Miyaura cross-coupling. This has enabled the rapid and efficient synthesis of an array of tripeptide derivatives encompassing novel biaryl moieties. The peptide derivatives show high activity against Gram-positive bacteria.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bengt Erik Haug, Wenche Stensen, John S. Svendsen,