Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366854 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Novel 5-aza-ellipticine derivatives were synthesized and tested as antitumor agents. The new compounds were prepared more readily than the analogous ellipticine derivatives, which are known to be potent anti-tumor agents Although the novel 5-aza-ellipticine derivatives are not as biologically active as their corresponding ellipticine analogues, the new compounds represent a new, readily accessible class of heteroaromatic catalytic inhibitors of topoisomerase II and possible anti-tumor agents.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Deborah L. Moody, Marcin Dyba, Teresa Kosakowska-Cholody, Nadya I. Tarasova, Christopher J. Michejda,