| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366952 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
Simplification of bottom ring and regioselective functionalization of the indolocarbazole unit of staurosporine (2) are described. The modification led to a new series of simplified staurosporine analogs, which exhibited significant inhibitory activity against Janus kinase 3 (JAK3). The structure–activity relationships (SAR) are discussed and a proposed binding model is also highlighted.
Graphical abstractThe modification of staurosporine led to a new series of potent JAK3 inhibitors is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shyh-Ming Yang, Ravi Malaviya, Lawrence J. Wilson, Rochelle Argentieri, Xin Chen, Cangming Yang, Bingbing Wang, Druie Cavender, William V. Murray,