Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists

A novel series of kynurenic acid amides, ring-enlarged derivatives of indole-2-carboxamides, was prepared and identified as in vivo active NR2B subtype selective NMDA receptor antagonists. The synthesis and SAR studies are discussed.

Graphical abstractStarting from indole- and benzimidazole-2-carboxamides as lead compounds, a novel series of kynurenic acid amide derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The synthesis and SAR studies are discussed.Figure optionsDownload full-size imageDownload as PowerPoint slide