| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366969 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
We report the synthesis and biochemical evaluation of new competitive inhibitors of the cytosolic (NADH-dependent) glycerophosphate dehydrogenase. The best tested compound, phosphono-propionohydroxamic acid, with a Ki of 6 μM, might be of interest as an anti-obesity drug.
Graphical abstractWe report the synthesis and biochemical evaluation of new competitive inhibitors of the cytosolic (NADH-dependent) glycerophosphate dehydrogenase. One compound, phosphono-propionohydroxamic acid, with a Ki of 6 μM, might be of interest as an anti-obesity drug.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Matthieu Fonvielle, Helene Therisod, Marion Hemery, Michel Therisod,