| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366976 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
The Staudinger reaction between a polymer-supported triphenylphosphine reagent and pseudo-disaccharide azides is successfully applied to synthesize a variety of substrate-mimic mycothiol analogs. Screening of this new group of analogs against the mycobacterial detoxification enzyme mycothiol-S-conjugate amidase (MCA) yielded several modest inhibitors (IC50 values around 50 μM) and provided additional structure–activity relationships for future optimization of inhibitors of MCA and its homologs.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Belhu B. Metaferia, Satyajit Ray, Jeremy A. Smith, Carole A. Bewley,