| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366983 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
A small molecule library of 1,3-dioxoisoindoline-5-carboxamides 4 was designed based on the pharmacophore model, synthesized and biologically evaluated as potential T-type calcium channel blockers. The most active compounds 4d and 4n show T-type calcium channel blocking activity with IC50 values of 0.93 and 0.96 μM, respectively.
Graphical abstractA small molecule library of 1,3-dioxoisoindoline-5-carboxamides 4 was designed, synthesized, and biologically evaluated as potential T-type calcium channel blockers. The most active compound shows blocking activity with IC50 value of 0.93 μM.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Hwa Sil Kim, Yoonjee Kim, Munikumar Reddy Doddareddy, Seon Hee Seo, Hyewhon Rhim, Jinsung Tae, Ae Nim Pae, Hyunah Choo, Yong Seo Cho,