| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366993 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
Potent and selective adamantane sulfone and sulfonamide inhibitors of 11-β-HSD-1 have been discovered. Selected compounds from these series have robust pharmacokinetic profiles and strongly inhibit liver, fat, and brain HSD1 for extended periods after oral dosing.
Graphical abstractThe synthesis of potent and selective adamantane sulfone and sulfonamide 11-β-HSD-1 inhibitors represented by 10 and 40 is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bryan Sorensen, Martin Winn, Jeff Rohde, Qi Shuai, Jiahong Wang, Steven Fung, Katina Monzon, William Chiou, DeAnne Stolarik, Hovis Imade, Liping Pan, Xiaoqing Deng, Linda Chovan, Kenton Longenecker, Russell Judge, Wenying Qin, Michael Brune, Heidi Camp,