| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367000 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
The synthesis of a series of novel C-linked nucleotide triphosphates is reported. These exhibit excellent agonist potency and selectivity for the P2Y2 receptor with a number of examples having EC50 values below 10 nM. Representative compounds from the N-linked and C-linked series showed enhanced metabolic stability compared with that of the natural ligand UTP.
Graphical abstractThe synthesis and P2Y2 activities of some novel C-linked nucleotide triphosphates are reported. These exhibit excellent agonist potency and selectivity for the P2Y2 receptor. Stability studies were carried out on representative compounds from the N-linked and C-linked series; these showed enhanced metabolic stability compared with that of UTP.Figure optionsDownload full-size imageDownload as PowerPoint slide
