Novel nucleotide triphosphates as potent P2Y2 agonists

The synthesis and P2Y2 activities of a novel series of nucleoside triphosphates are described. Many of these compounds were potent agonists of the P2Y2 receptor.

Graphical abstractThe synthesis and P2Y2 activities of a novel series of UTP analogs bearing ‘unnatural’ bicyclic bases in place of the uracil are described. Many of these compounds were potent and selective agonists of the P2Y2 receptor.Figure optionsDownload full-size imageDownload as PowerPoint slide