| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367054 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
Starting from a potent ketone-based inhibitor with poor drug properties, incorporation of P2–P3 elements from a ketoamide-based inhibitor led to the identification of a hybrid series of ketone-based cathepsin K inhibitors with better oral bioavailability than the starting ketone.
Graphical abstractStarting from a potent ketone-based inhibitor with poor drug properties, incorporation of P2–P3 elements from a ketoamide-based inhibitor led to the identification of a hybrid series of ketone-based cathepsin K inhibitors with better oral bioavailability than the starting ketone.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David G. Barrett, John G. Catalano, David N. Deaton, Stacey T. Long, Robert B. McFadyen, Aaron B. Miller, Larry R. Miller, Vicente Samano, Francis X. Tavares, Kevin J. Wells-Knecht, Lois L. Wright, Hui-Qiang Q. Zhou,