| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367056 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
By focusing on the P1 portion of the piperidine β-sulfone ligands we identified a motif that induces selectivity and resulted in a series of TACE inhibitors that demonstrated excellent in vitro potency against isolated TACE enzyme and excellent selectivity over MMPs 1, 2, 9, 13, and 14.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jeffrey S. Condon, Diane Joseph-McCarthy, Jeremy I. Levin, Henry-Georges Lombart, Frank E. Lovering, Linhong Sun, Weiheng Wang, Weixin Xu, Yuhua Zhang,