| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367057 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Libraries of mifepristone analogs, MP-Acids, were shown to be potent GR antagonists in binding and cell-based functional screens. A high-throughput pharmacokinetic selection strategy was devised to identify MP-Acids with liver-targeting profiles. These conjugates were tested in in vivo models to evaluate liver versus systemic GR antagonism.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bradley J. Backes, Gregory L. Hamilton, Phong Nguyen, Denise Wilcox, Steven Fung, Jiahong Wang, Marlena Grynfarb, Annika Goos-Nilsson, Peer B. Jacobson, Thomas W. von Geldern,