| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367058 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
The naturally occurring fungal metabolite kojic acid and its manganese and zinc complexes have been evaluated as potential radioprotectors in mice. Their toxicity and radioprotective activity (survival rate) have been determined and compared with that of WR-2721 (amifostine). The results of in vivo radioprotection showed that these compounds exhibited significant radioprotective effects against lethal dose of γ-irradiation in mice.
Graphical abstractThe naturally occurring fungal metabolite kojic acid and its manganese and zinc complexes have been evaluated as potential radioprotectors in mice. Their toxicity and radioprotective activity (survival rate) have been determined and compared with those of WR-2721 (amifostine). The results of in vivo radioprotection showed that these compounds exhibited significant radioprotective effects against lethal dose of γ-irradiation in mice.Figure optionsDownload full-size imageDownload as PowerPoint slide
