| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367064 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
We describe a novel series of potent inhibitors of human β-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5 Å crystal structure of inhibitor 32 bound to BACE is provided.
Graphical abstractWe describe a novel series of potent inhibitors of human β-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5 Å crystal structure of inhibitor 32 bound to BACE is provided.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John N. Freskos, Yvette M. Fobian, Timothy E. Benson, Michael J. Bienkowski, David L. Brown, Thomas L. Emmons, Robert Heintz, Alice Laborde, Joseph J. McDonald, Brent V. Mischke, John M. Molyneaux, Joseph B. Moon, Patrick B. Mullins, D. Bryan Prince,