| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367066 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Quinones such as Calothrixins A and B display a range of biological properties. As part of our ongoing studies to elucidate the mechanism of action of the Calothrixins, several related quinones were synthesized and tested for biological activity. The results of the structure–activity relationship (SAR) studies are reported here.
Graphical abstractThe biological activities of Calothrixin B and six related analogues against three cell lines are reported. The results of the structure–activity relationship study are discussed.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paul H. Bernardo, Christina L.L. Chai, Maurice Le Guen, Geoffrey D. Smith, Paul Waring,