Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367081 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
An efficient and convergent method for the synthesis of mannose-1-phosphate prodrugs is described as a potential therapy for congenital disorders of glycosylation-Ia (CDG-Ia). The key feature of the proposed approach is the silver assisted nucleophilic substitution of 2,3,4,6-tetra-O-protected-α-d-mannopyranosyl bromides with various silver phosphate salts to afford mono, di, and tri-mannopyranosyl phosphates. A preliminary biological evaluation of the synthesized phosphate prodrugs has been carried out.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Renaud Hardré, Amira Khaled, Alexandra Willemetz, Thierry Dupré, Stuart Moore, Christine Gravier-Pelletier, Yves Le Merrer,