Synthesis and anticonvulsant activity of sulfonamide derivatives-hydrophobic domain

A series of sulphonamide derivatives (1–11) were synthesized in good yield and evaluated for their possible anticonvulsant activity and neurotoxic study. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Majority of the compounds were active in MES and scPTZ tests. All the compounds were less toxic than the standard drug phenytoin.

Graphical abstractN- (6-‘substituted’-1,3-benzothiazol-2-yl)-4{[(‘substituted’ amino) carbonothionyl] amino} benzenesulfonamides (1–6) and N-(4-‘substituted’ phenyl)-4-{[‘substituted’ amino carbonothionyl] amino} benzenesulfonamides (7–11) were synthesized and evaluated for their possible anticonvulsant, neurotoxic studies and their potential hydrophobic domain has been described.Figure optionsDownload full-size imageDownload as PowerPoint slide