| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367103 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
A series of 4-aminopyrimidines (1) was identified as novel HIV inhibitors of unknown molecular target. Structural modifications were carried out to establish its SAR and identify the linking site for target identification. A number of analogs were found to possess single digit inhibitory activity for HIV replication. Several analogs with various potential linkers, including a biotinated analog, also exhibited excellent potency, and could serve as tools for the identification of novel anti-HIV targets.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Venkat R. Gadhachanda, Baogen Wu, Zhiwei Wang, Kelli L. Kuhen, Jeremy Caldwell, Helmut Zondler, Harald Walter, Mark Havenhand, Yun He,