| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367153 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K6H2[TiW11CoO40], exhibiting Ki values of 0.140 μM (NTPDase1), 0.910 μM (NTPDase2), and 0.563 μM (NTPDase3). One of the compounds, (NH4)18[NaSb9W21O86], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase inhibition might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.
Graphical abstractPolyoxotungstates were identified as novel potent inhibitors of ecto-NTPDases. [TiW11CoO40]8− (7) exhibited a Ki value of 140 nM at rat E-NTPDase1.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christa E. Müller, Jamshed Iqbal, Younis Baqi, Herbert Zimmermann, Anita Röllich, Holger Stephan,