| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367159 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
This communication details the synthesis, biological activity, and binding mode of a novel class of 2-benzimidazole substituted pyrimidines. The most potent analogs disclosed showed low nanomolar activity for the inhibition of Lck kinase and a representative analog was co-crystallized with Hck (a structurally related member of the Src family kinases).
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mark Sabat, John C. VanRens, Matthew J. Laufersweiler, Todd A. Brugel, Jennifer Maier, Adam Golebiowski, Biswanath De, Vijayasurian Easwaran, Lily C. Hsieh, Richard L. Walter, Marlene J. Mekel, Artem Evdokimov, Michael J. Janusz,