Identification of non-furan containing A2A antagonists using database mining and molecular similarity approaches

Database searching led to the identification of potent A2A antagonists which do not contain the privileged furan moiety and which show selectivity over A1 receptors. Simple substructure searching on a proprietary database identified compounds with activities in the low nM range. A targeted approach to the identification of non-furan containing compounds resulted in the identification of two novel series, with potency, selectivity and directional SAR from screening 113 compounds.

Graphical abstractIdentification of potent, non-furan containing A2A antagonists using database mining.Figure optionsDownload full-size imageDownload as PowerPoint slide