| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367165 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of 5-arylamino-6-chloro-1H-indazole-4,7-diones were synthesized and evaluated for their inhibitory activity on protein kinase B/Akt. The compounds exhibited a potent Akt1 inhibitory activity. Further mechanistic study revealed that they might have dual inhibitory effects on both activity and phosphorylation of Akt1 in PC-3 tumor cell line.
Graphical abstract5-Arylamino-6-chloro-1H-indazole-4,7-diones were synthesized and evaluated for their inhibitory activity on protein kinase B/AKT. The 5-arylamino-6-chloro-1H-indazole-4,7-diones exhibited a potent Akt1 inhibitory activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jong Hee Ko, Seung Woo Yeon, Jung Su Ryu, Tae-Yong Kim, Eun-Ha Song, Hea-Jung You, Rae-Eun Park, Chung-Kyu Ryu,