Article ID Journal Published Year Pages File Type
1367169 Bioorganic & Medicinal Chemistry Letters 2006 4 Pages PDF
Abstract
The enhancement by one order of magnitude of inhibition potency exhibited by cyclopropanecarbonyl derivatives relative to the corresponding isopropylcarbonyl analogs is probably caused by metal chelating and hydrogen bonding interactions at the ligand-receptor binding site.
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Physical Sciences and Engineering Chemistry Organic Chemistry
Preview
Enzyme inhibition potency enhancement by active site metal chelating and hydrogen bonding induced conformation-restricted cyclopropanecarbonyl derivatives
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