| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367173 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
A series of 2-arylbenzimidazoles was synthesized and found to bind with high affinity to the human histamine H4 receptor. Structure–activity relationships were investigated through library preparation and evaluation as well as traditional medicinal chemistry approaches, leading to the discovery of compounds with single-digit nanomolar affinity for the H4 receptor.
Graphical abstractA series of 2-arylbenzimidazoles was synthesized and found to bind with high affinity to the human histamine H4 receptor.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alice Lee-Dutra, Kristen L. Arienti, Daniel J. Buzard, Michael D. Hack, Haripada Khatuya, Pragnya J. Desai, Steven Nguyen, Robin L. Thurmond, Lars Karlsson, James P. Edwards, J. Guy Breitenbucher,