| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367179 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
The discovery of genotoxic amino acids derived from phenylglycine, and posessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.
Graphical abstractThe discovery and synthesis of genotoxic (haloaryl)glycines is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alicia Boto, Juan A. Gallardo, Rosendo Hernández, Francisco Ledo, Ana Muñoz, José R. Murguía, Mauricio Menacho-Márquez, Aurelio Orjales, Carlos J. Saavedra,