| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367182 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of potent steroidal glucocorticoid receptor antagonists has been discovered. After conjugation to cholic acid, the compounds retained an affinity for GR in vitro and had modest in vivo efficacy.
Graphical abstractA series of potent steroidal glucocorticoid receptor antagonists has been discovered. After conjugation to cholic acid, the compounds retained an affinity for GR in vitro and had modest in vivo efficacy.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Steven J. Richards, Thomas W. von Geldern, Peer Jacobson, Denise Wilcox, Phong Nguyen, Lars Öhman, Marie Österlund, Birgitta Gelius, Marlena Grynfarb, Annika Goos-Nilsson, Jiahong Wang, Steven Fung, Masha Kalmanovich,