Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367192 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
In this study, we synthesized a series of enantiomerically pure (2R,3R)-disubstituted tetrahydropyrans with diverse functional groups. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show the relevance for antiproliferative activity of the α,β-unsaturated ester side chain at position 2 of the THP ring.
Graphical abstractThe synthesis and in vitro antitumor activity of a series of enantiomerically pure (2R,3R)-disubstituted tetrahydropyrans against human solid tumor cells are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Romen Carrillo, Leticia G. León, Tomás Martín, Víctor S. Martín, José M. Padrón,