| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367298 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
The synthesis, structure, and biological evaluation of a series of novel rifamycin derivatives, Rifastures (RFA) with potent anti-tuberculosis activity are presented. Some of these derivatives showed higher in vitro activity than rifabutin and rifampicin against not only Mycobacterium tuberculosis strains but also against MAC and Mycobacterium kansasii.
Graphical abstractThe synthesis and biological evaluation of novel rifamycin derivatives are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
José Barluenga, Fernando Aznar, Ana-Belén García, María-Paz Cabal, Juan J. Palacios, María-Angela Menéndez,