| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367302 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
We have previously reported artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) using a cationic polymer. However, this polymer alone cannot deliver any gene into living cells. In the present work, we modified the signal-responsive polymer to the RGD peptide for the introduction of a polymer/DNA complex into living cells and succeeded in regulating the gene expression responding to intracellular PKA activation.
Graphical abstractDevelopment and evaluation of RGD peptide modified signal-responsive gene carrier are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jun Oishi, Moeko Ijuin, Tatsuhiko Sonoda, Jeong-Hun Kang, Kenji Kawamura, Takeshi Mori, Takuro Niidome, Yoshiki Katayama,