Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367315 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The synthesis of a new class of 9-(S)-dihydroerythromycin derivatives and their anti-inflammatory activity on in vivo PMA assay are described. Modifying the desosamine sugar on the C-3′ amino group, it was possible to differentiate between anti-biotic and anti-flammatory action. The compounds are completely devoid of anti-microbial effects but their anti-inflammatory properties are enhanced. These results strongly suggest the potential of macrolides as a new class of anti-inflammatory agents.
Graphical abstractThe synthesis of a new class of 9-(S)-dihydroerythromycin derivatives and their anti-inflammatory activity are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
A. Mereu, E. Moriggi, M. Napoletano, C. Regazzoni, S. Manfredini, T.P. Mercurio, F. Pellacini,