| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367325 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Chalcones are known to exhibit antimitotic properties caused by inhibition of tubulin polymerisation. We describe here the effects of different α-substitutions, in particular α-fluorination, on the structure and biological activity of a series of chalcones.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nicholas J. Lawrence, Richard P. Patterson, Li-Ling Ooi, Darren Cook, Sylvie Ducki,