| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367327 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A novel class of tetrahydroindolone-derived carbamates has been discovered whose members are potent Kv1.5 blockers. The in vitro data show that compounds 6 and 29 are quite potent. They are also very selective over hERG (>450-fold) and L-type calcium channels (>450-fold).
Graphical abstractA novel class of tetrahydroindolone-derived carbamates has been discovered whose members are potent Kv1.5 blockers. The in vitro data show that compounds 6 and 29 are quite potent. They are also very selective over hERG (>450-fold) and L-type calcium channels (>450-fold).Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrew Fluxe, Shengde Wu, James B. Sheffer, John M. Janusz, Michael Murawsky, Gina M. Fadayel, Bin Fang, Michelle Hare, Laurent Djandjighian,