Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367336 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
This letter describes the discovery of a novel series of potent Kv1.5 ion channel antagonists based on a diisopropyl amide scaffold. Structure–activity relationships of functionalized analogs are discussed. Key compound 1-(3-(diisopropylcarbamoyl)-2-phenyl-3-(pyridin-3-yl)propyl)-3-(2-fluorobenzyl)urea (10) exhibits significant atrial-selective effects in an in vivo model.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kausik K. Nanda, M. Brad Nolt, Matthew J. Cato, Stefanie A. Kane, Laszlo Kiss, Robert H. Spencer, Jixin Wang, Joseph J. Lynch, Christopher P. Regan, Gary L. Stump, Bing Li, Rebecca White, Suzie Yeh, Michael J. Bogusky, Mark T. Bilodeau,