Article ID Journal Published Year Pages File Type
1367336 Bioorganic & Medicinal Chemistry Letters 2006 5 Pages PDF
Abstract

This letter describes the discovery of a novel series of potent Kv1.5 ion channel antagonists based on a diisopropyl amide scaffold. Structure–activity relationships of functionalized analogs are discussed. Key compound 1-(3-(diisopropylcarbamoyl)-2-phenyl-3-(pyridin-3-yl)propyl)-3-(2-fluorobenzyl)urea (10) exhibits significant atrial-selective effects in an in vivo model.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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