Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367348 | Bioorganic & Medicinal Chemistry Letters | 2006 | 7 Pages |
Abstract
Benzimidazole-based allosteric inhibitors of the hepatitis C virus (HCV) NS5B polymerase were diversified to a variety of topologically related scaffolds. Replacement of the polar benzimidazole core by lipophilic indoles led to inhibitors with improved potency in the cell-based subgenomic HCV replicon system. Transposing the indole scaffold into a previously described series of benzimidazole–tryptophan amides generated the most potent inhibitors of HCV RNA replication in cell culture reported to date in this series (EC50 ∼ 50 nM).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pierre L. Beaulieu, James Gillard, Darren Bykowski, Christian Brochu, Nathalie Dansereau, Jean-Simon Duceppe, Bruno Haché, Araz Jakalian, Lisette Lagacé, Steven LaPlante, Ginette McKercher, Elaine Moreau, Stéphane Perreault, Timothy Stammers,