| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367353 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jae Yeol Lee, Seong Jun Park, Sung Jun Park, Min Joo Lee, Hyewhon Rhim, Seon Hee Seo, Ki-Sun Kim,