Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367360 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
The following structurally diverse 5-substituted-2′-deoxyuridine nucleosides displayed potent in vitro antileishmanial activity: 5-formyl, 5-(2,2,-dicyanovinyl)-, 5-(2-cyano-2-ethoxycarbonylvinyl), 5-(2-cyano-2-methoxycarbonylvinyl)-, 5-(2-amino-3-cyano-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4-yl)- and related congeners, and the 5-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-4H-pyrazol-4-ylidene) group.
Graphical abstractA series of 5-substituted pyrimidine nucleosides with R substituents ranging from formyl, to dicyanovinyl, to substituted chromenes, and including a pyrazolone, were all potent inhibitors of Leishmania donovani promastigotes.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paul F. Torrence, Xuesen Fan, Xinying Zhang, Philippe M. Loiseau,