| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367369 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
An efficient synthesis of the folate receptor (FR) targeting conjugate EC145 is described. EC145 is a water soluble derivative of the vitamin folic acid and the potent cytotoxic agent, desacetylvinblastine monohydrazide. Both molecules are connected in regioselective manner via a hydrophilic peptide spacer and a reductively labile disulfide linker.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Iontcho R. Vlahov, Hari Krishna R. Santhapuram, Paul J. Kleindl, Stephen J. Howard, Katheryn M. Stanford, Christopher P. Leamon,