Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367380 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D under thiol-based reducing conditions. Achieving DNA cleavage under these reducing conditions is key to anticancer activity, as the most active compound, 1-methoxydiazofluorene, inhibits the proliferation of HeLa cells.
Graphical abstractThe synthesis, DNA cleaving, and anti-proliferative properties of electronically modulated diazofluorenes are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wei Zeng, T. Eric Ballard, Alexander G. Tkachenko, Virginia A. Burns, Daniel L. Feldheim, Christian Melander,