| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367382 | Bioorganic & Medicinal Chemistry Letters | 2006 | 7 Pages |
Abstract
A water-soluble albumin-binding prodrug of doxorubicin [EMC-Gly-Gly-Gly-Arg-Arg-DOXO (EMC, 6-maleimidocaproic acid)] was developed that is cleaved specifically by the tumor-associated protease urokinase-type plasminogen activator (uPA).
Graphical abstractA water-soluble albumin-binding prodrug of doxorubicin (1) was developed that is cleaved specifically by the tumor-associated protease urokinase-type plasminogen activator (uPA).Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Da-Eun Chung, Felix Kratz,