Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367390 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The synthesis and structure–activity relationship (SAR) of novel and highly potent positive allosteric modulators of AMPA receptors, 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, are described. These studies indicated that higher potency was achieved with ortho substitution of the distal (D) phenyl of the 3-biphenyl ring and resulted in the discovery of a potent pyrrole LY2059346 (23q), that was selected for further evaluation in in vitro native tissue assays and in vivo experiments.
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Related Topics
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Authors
Hamideh Zarrinmayeh, Eric Tromiczak, Dennis M. Zimmerman, Nancy Rankl, Ken H. Ho, Esteban Dominguez, Ana Castaño, Ana Escribano, Carmen Fernandez, Alma Jimenez, William J. Hornback, Eric S. Nisenbaum,