| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367392 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of conformationally restricted inhibitors of human soluble epoxide hydrolase (sEH) has been developed. Inhibition potency of the described compounds ranges from 4.2 μM to 1.1 nM against recombinant sEH. N-(1-Acetylpiperidin-4-yl)-N′-(adamant-1-yl) urea (5a) was found to be a potent inhibitor (IC50 = 7.0 nM) that was also orally bioavailable in canines.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paul D. Jones, Hsing-Ju Tsai, Zung N. Do, Christophe Morisseau, Bruce D. Hammock,