Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands

Design and synthesis of potent MC4 selective agonists based on cyclohexylpiperidine derived cyclic urea, oxazolidinones, and sulfonamide based privileged structures are disclosed.

Graphical abstractThe design and synthesis of potent MC4 agonists 19b and 27 are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide