| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367465 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Pyrimidino-thiazolyl carbonitriles were prepared that are potent VEGFR-2 (KDR) kinase inhibitors. The modification of lead structures resulted in 3m which exhibited the best overall profile in KDR inhibitory activity, iv/po pharmacokinetics, and reduced hERG affinity.
Graphical abstractPyrimidino-thiazolyl carbonitriles were prepared that are potent VEGFR-2 (KDR) kinase inhibitors. The modification of lead structures resulted in 3m which exhibited the best overall profile in KDR inhibitory activity, iv/po pharmacokinetics, and reduced hERG affinity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
John T. Sisko, Thomas J. Tucker, Mark T. Bilodeau, Carolyn A. Buser, Patrice A. Ciecko, Kathleen E. Coll, Christine Fernandes, Jackson B. Gibbs, Timothy J. Koester, Nancy Kohl, Joseph J. Lynch, Xianzhi Mao, Debra McLoughlin, Cynthia M. Miller-Stein,