Article ID Journal Published Year Pages File Type
1367468 Bioorganic & Medicinal Chemistry Letters 2006 4 Pages PDF
Abstract

A series of pyrrolobenzodiazepine–azepane conjugates linked through different alkane spacers have been prepared and their DNA thermal denaturation studies have been carried out. One of the compound (4b), elevates the DNA helix melting temperature of the CT-DNA by 2.0 °C after incubation for 36 h at 37 °C.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , ,