Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367468 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of pyrrolobenzodiazepine–azepane conjugates linked through different alkane spacers have been prepared and their DNA thermal denaturation studies have been carried out. One of the compound (4b), elevates the DNA helix melting temperature of the CT-DNA by 2.0 °C after incubation for 36 h at 37 °C.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ahmed Kamal, D. Rajasekhar Reddy, P.S. Murali Mohan Reddy, Rajendar,