| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367472 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Imidazo[1,2-a]pyrimidines are GABAA receptor benzodiazepine binding site ligands which can exhibit functional selectivity for the α3 subtype over the α1 subtype. SAR studies to optimize this functional selectivity are described.
Graphical abstractImidazo[1,2-a]pyrimidines are GABAA receptor benzodiazepine binding site ligands which can exhibit functional selectivity for the α3 subtype over the α1 subtype. SAR studies to optimize this functional selectivity are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Imidazo[1,2-a]pyrimidines as functionally selective GABAA ligands](/preview/png/1367472.png "First Page Preview: Imidazo[1,2-a]pyrimidines as functionally selective GABAA ligands")
Authors
Wesley P. Blackaby, John R. Atack, Frances Bromidge, José L. Castro, Simon C. Goodacre, David J. Hallett, Richard T. Lewis, George R. Marshall, Andrew Pike, Alison J. Smith, Leslie J. Street, David F.D. Tattersall, Keith A. Wafford,